摘要
以2’,4’-二氟联苯为原料,以乙酰氯为酰化剂,二氯甲烷为溶剂,经Friedel-Crafts酰化反应制备了4-(2’,4’-二氟苯基)苯乙酮,确定的最佳反应条件为:乙酰氯的添加温度低于15℃,反应温度25℃,二氟联苯/乙酰氯/三氯化铝(摩尔比)为1:1.22:1.34,反应时间为3 h,并对后处理过程进行了改进,4-(2’,4’-二氟苯基)苯乙酮的最佳收率达到96.3％(基于二氟联苯),熔点70～72℃,纯度98.5％。
Using acetyl chloride as acetylating agent and dichloromethane as solvent, the 4-(2',4'-difluorophenyl) acetophenone was synthesized from 2', 4'-difluorobiphenyl via Friedel-Crafts reaction. The optimal synthetic conditions were obtained as follows: n(2',4'-difluorobiphenyl): n(acetyl chloride): n(AlCl_3)=1:1.22:1.34, addition temperature of ace tyl chloride<15℃, reaction temperature 25℃, reaction time 3h, and the after treatment of the product was improved also. The molar yield of product is over 96%(based on 2',4'-difluorobiphenyl), m.p. 70-72℃, purity 98.5%.
出处
《精细石油化工》
CAS
CSCD
北大核心
2004年第4期21-24,共4页
Speciality Petrochemicals
