摘要
[目的]观察艾迪莎治疗溃疡性结肠炎的临床疗效及组织学特点,并同柳氮磺胺吡啶(SASP)比较。[方法]选择5 1例内镜确诊为轻、中度溃疡性结肠炎患者。取病理观察其组织学特点,随机分组:艾迪莎组和SASP组。分别给予艾迪莎1.0g 3次/d口服和SASP 1.0 g 4次/d口服,疗程6周。治疗后进行症状评分,对药物疗效进行评价。同时复查肠镜取病理观察组织学的变化。[结果]在服药6周后艾迪莎组患者主观评价病情明显好于SASP组,有统计学差异。治疗6周后肠镜下病变明显好转率好于SASP组。有统计学差异。治疗6周后肠镜检查组织学明显好转率高于SASP组,有统计学差异。[结论]艾迪莎治疗溃疡性结肠炎能明显减少中性粒细胞和嗜酸细胞,浆细胞的浸润,减轻炎性反应,促进愈合。
Objective To investigate clinical effect and histology characteristics of adis in the treatment of ulcerative colitis and to compare with those of adis.[Methods ] To select 51 patients of Ulcerative Colitis of low and medium degree diagonised by gastroscope. To observe the histological characteristics by sample. To divide the patients into 2 groups randomly: Group Adis and Group SASP. To treat with Adis 1.0 three times a day and SASP 1.0 four times a day accordingly, period of 6 weeks. To make an investigation on the effect of the medicine after the treatment. At the same time, observe the sample to find out the changes in histological characteristics. [Result] The Adis Group feel much better than SASP Group after the 6 week treatment, there's obvious statistical differences. The pathological changes of Adis Group is mending much better than SASP Group observed by gastroscope, there's obvious statistical differences. The histological changes of Adis Group is mending much better than SASP Group observed by gastroscope, there's obvious statistical differences. [Conclusion]Treated with Adis, patients of ulcerative colitis can be greatly improved in amelioration inflammation mucosal small vessels lesion, decrease neutrophil, acidophil plasmcell, infiltrate, relieve response of inflammation, meanwhile anti-xanthine oxidase leucocyte mediated oxygen-derived free radidicals formation, prelude acceleration inflamed healing key points histology alteration.
出处
《大连医科大学学报》
CAS
2005年第2期110-112,共3页
Journal of Dalian Medical University
