摘要
目的:通过对兔脉络膜上腔注射肾上腺素诱发浆液性视网膜脱离,探讨交感-肾上腺髓质系统在中心性浆液性脉络膜视网膜病变(centralserouschori-oretinopathy,CSC)发病中的作用。方法:将肾上腺素溶液从有色兔1眼的脉络膜上腔注入,于注射后1h及1,2,3,6,10d对其双眼行眼底彩色照相、荧光素眼底血管造影(fundusfluoresceinangiography,FFA)、吲哚青绿血管造影(indocyaninegreenangiography,ICGA)及组织病理学检查。结果:注射后1h,ICGA见区域性脉络膜缺血及其周围扩张的脉络膜血管,FFA可见视网膜色素上皮(retinalpigmentepithelium,RPE)剧烈荧光渗漏。光学显微镜镜下可见神经感觉层与RPE间有浆液积聚,光感受器外节排列紊乱。注射后2～10d,神经感觉层下积液逐渐减少至消失,RPE渗漏减少,脉络膜缺血区域减小至消失,RPE脱色素,光感受器外节仍然轻度紊乱。结论:肾上腺素可导致脉络膜静脉及毛细血管淤血并继发视网膜神经感觉层浆液性脱离,说明因应激所致的交感-肾上腺髓质系统活动增加可能是CSC发生的根本原因。
· AIM: To evaluate the function of sympathetico-adrenomedullary system in the pathogenesis of central serous choroidoretinopathy (CSC) by injection of adrenaline into the epichoroidal space of rabbits to induce serous neurosensory retina detachment.· METHODS: Adrenaline solution was injected into the pigmented rabbits' epichoroidal space. The fundi of injected eyes were examined by color fundus photography, fundus fluorescein angiography ( FFA), indocyanine green angiography (ICGA) and histopathology at 1h and 1, 2, 3, 6 ,10d after the injection.· RESULTS: FFA showed RPE was leaking fluorescein. ICGA showed local choroidalischemia and dilated choroidal vessels in the surroundings. Light microscope demonstrated that outer photoreceptor segments disorganized and that serum accumulated between neurosensory retina and RPE at 1h after injection. Gradually From 2d to 10d after injection, these phenomena faded away except for the depigmented RPE and slightly disorganized outer photoreceptor segments.· CONCLUSION: Adrenaline can result in choroidal capillary, venous congestion and serous neurosensory retina detachment. Increased sympathetico-adrenomedullary system activities in stress may be the cause of central serous choroidoretinopathy (CSC).·
出处
《国际眼科杂志》
CAS
2005年第2期239-242,共4页
International Eye Science
