蚊虫基因对疟原虫发育的影响
EffectsofMosquitoGenesonPlasmodiumDevelopment
摘要
疟原虫在传播至脊椎动物宿主之前 ,必须在其传播媒介按蚊体内经历一个复杂的发育过程。蚊吸食了带有疟原虫配子体的血液后 ,配子体即开始在蚊体内发育 :动合子穿过蚊胃上皮细胞后转变为卵囊。疟原虫入侵蚊胃的同时 ,蚊的先天免疫系统被激活 ,但是 ,迄今为止没有公开发表的证据表明蚊虫的基因能够影响疟原虫的发育。本文通过基因抑制的方法发现 :在冈比亚按蚊体内 ,存在着对疟原虫发育具有保护作用的C型凝集素 (CTLs)及对其有拮抗作用的富含亮氨酸的蛋白质 (LRR)。
出处
《国外医学（寄生虫病分册）》
2005年第2期89-92,F003,共5页
Parasitic Diseases Foreign Medical Sciences
参考文献27
-
1Sinden RE. Molecular interactions between Plasmodium and its insect vectors. Cell Microbiol, 2002,4 ( 11 ): 713-724.
-
2Collins FH, Sakai RK, Vernick KD. Genetic selection of a Plasmodium-refractory strain of the malaria vector Anopheles gambiae.Science, 1986,234 ( 4776 ): 607-610.
-
3Niaré O. Genetic loci affecting resistance to human malaria parasites in a west African mosquito vector population. Science, 2002,298(5591):213-216.
-
4Dimopoulos G, Seeley D, Wolf A, et al. Malaria infection of the mosquito Anopheles gambiae activates immune-responsive genes during critical transition stages of the parasite life cycle. EMBO J,1998,17:6115-6123.
-
5Dimopoulos G, Christophides GK, Meister S, et al. Genome expression analysis of Anopheles gambiae: Responses to injury, bacterial challenge, and malaria infection. Proc Natl Aead Sci USA,2002,99(13): 8814-8819.
-
6Christophides GK, Zdobnov E, Barillas-Mury C, et al. Immunityrelated genes and gene families in Anopheles gambiae. Science,2002,298(5591 ): 159-165.
-
7Holt RA, Subramanian GM, Halpern A, et al. The genome sequence of the malaria mosquito Anopheles gambiae. Science, 2002,298(5591): 129-149.
-
8Drickamer K, Taylor ME. Biology of animal lectins. Annu Rev Cell Biol, 1993,9: 237-264.
-
9Vasselon T, Detmers PA. Toll receptors: a central element in innate immune responses. Infect irnmun, 2002,70(3): 1033-1041.
-
10Blandin S, Moita LF, Kocher T, et al. Reverse genetics in the mosquito Anopheles gambiae: targeted disruption of the defensin gene. EMBO Reports, 2002,3(9) :852-856.
-
1刘田民,李慧珠,王凤芸,潘李珍.鼠疟原虫动合子体外培养及其生物学活性的研究[J].动物学报,1989,35(4):436-437.
-
2李慧珠,刘田民,王风芸.约氏疟原虫蚊期体外培养:动合子和动合子形成的扫描电镜观察[J].动物学报,1989,35(3):333-334.
-
3高兴政.离体培养约氏疟原虫动合子形成的扫描电镜观察[J].中国寄生虫学与寄生虫病杂志,1989,7(1):53-56.
-
4刘金明,杨柏林.疟原虫配子体活力的生理节律[J].国外医学（寄生虫病分册）,1991,18(3):102-105.
-
5朱晓华,石佑恩.血吸虫脂肪酸结合蛋白分子及其免疫保护性的研究进展[J].国外医学（寄生虫病分册）,2004,31(5):202-204.
-
6李慧珠,王风芸,吴春容.鸡疟原虫动合子迁移途径的超微结构研究[J].寄生虫与医学昆虫学报,1994,1(2):1-5.
-
7王娜.冈比亚按蚊Ⅳ型胶原蛋白基因:克隆、系统发育、与吸血和感染相关的中肠表达[J].国外医学（寄生虫病分册）,2004,31(6):282-282.
-
8黄亚铭,傅伟忠,赵忻,黄若密,韦海燕.大劣按蚊对食蟹猴疟原虫配子体最佳敏感期观察[J].中国公共卫生,1993,9(11):500-501. 被引量：1
-
9苟俊,郝宏兴,张静茹,段建华.约氏疟原虫动合子的体外纯培养[J].中国寄生虫病防治杂志,2003,16(2):87-88.
-
10魏秋芬,高兴政.抗蚊中肠抗体对斯氏按蚊体内约氏疟原虫卵囊发育的影响[J].中国寄生虫学与寄生虫病杂志,2000,18(4):197-199. 被引量：1
