摘要
目的:观察心可舒胶囊(XKS)对犬心脏血流动力学及心肌耗氧量的影响。方法:采用BL 410生物机能实验系统检测犬心脏血流动力学,同时测定冠状动脉的血氧含量。结果:XKS高剂量组可显著性降低犬心脏左室收缩压、左室舒张压、左室收缩末期压、左室最大收缩压,缩短收缩开始至最大收缩压的时间间隔,降低最大舒张压绝对值,与生理盐水组相比较有显著性差异,(P <0 0 5 )。结论:XKS可能通过缩短收缩期、延长心舒期、降低心脏前负荷。
Objective :To observe effects of XinKeShu(XKS) capsule on hemodynamics and myocardium oxygen consumption of dog. Methods :Cardic hemodynamics was detected by BL-410 biological function experiment systems,and blood oxygen content was measured at the same time. Results :Indices as LVSP,LVDP,LVEDP,dp/dtmax,t-dp/dtmax and ascended-dp/dtmax all significantly decreased in XKS capsule group,compared with normal saline group( P <0.05). Conclusion :Pharmacological effects of XKS capsule in treating ischemic heart disease may be partly through the shortening of systole,lengthening of diastole,decreasing of heart preload and afterload,and inhibition of myocardium contractility.
出处
《中医药学刊》
2005年第5期854-856,共3页
Study Journal of Traditional Chinese Medicine
关键词
心可舒胶囊
心脏血流动力学
心肌耗氧量
犬
Xin Ke Shu capsule
hemodynamics
myocardium oxygen consumption
dog
