摘要
对３４例急性脑外伤患者脑脊液中精氨酸加压素（ＡＶＰ）和血管紧张素Ⅱ（ＡＴ－ＩＩ）的含量进行放免测定。结果：脑外伤后４８ｈ与６～１０天脑脊液中ＡＶＰ和ＡＴ－ＩＩ的平均含量明显升高；ＧＣＳ≤８分者脑脊液中ＡＶＰ的平均含量高于ＧＣＳ＞８分者（Ｐ＜０．０５）；脑脊液压力≥１．９６ｋＰａ（２００ｍｍＨ＿２Ｏ）组ＡＶＰ和ＡＴ－ＩＩ的平均含量高于脑脊液压力＜１．９６ｋＰａ（２００ｍｍＨ＿２Ｏ）组（Ｐ＜０．０５）。提示：ＡＶＰ和ＡＴ－ＩＩ参与了颅脑损伤的病理生理过程。
Levels of arginin-vasopressin(AVP)andangiotensinⅡ(AT-Ⅱ)were determ ined byradioimmunoassay in the cerebrospinal fluid (CSF)of 34 patients with acute head injury.The mean val-ues of AVP and AT-Ⅱ in the CSF were significantlyincreased 48 hrs .and 6-10days after head injury ;the mean values of A VP were higher in patients withGCS≤8 than those with GCS>8(P<0.05);and the mean values of AVP and AT-Ⅱ were higher in pa-tients with CSF pressure≥1.96 kPa(200mmH_2O)than those with the pressure<1.96kPa(P<0.05),Itis suggested that AVP and AT-Ⅱ are involved in thepathophysio logic mechanism of head injury.
出处
《中国危重病急救医学》
CSCD
1994年第6期337-339,共3页
Chinese Critical Care Medicine
