摘要
目的:研究中药川芎嗪(TMP)对实体肿瘤的疗效及其可能的作用机理。方法:本研究运用Lewis肺癌小鼠模型,观察TMP对小鼠Lewis肺癌的疗效、免疫功能、生存质量及不良反应的影响。结果:TMP治疗小鼠Lewis肺癌能抑制肿瘤的生长,稳定病灶,提高荷瘤小鼠的生存质量,改善免疫功能。结论:TMP对小鼠Lewis肺癌有明显疗效,其作用机理与其本身对Lewis肺癌实体瘤有抑制作用和提高荷瘤小鼠免疫功能有关。
AIM: To study the therapeutic effects of tetramethylpyrazine (TMP) in mice and possible mechanism. METHODS: The mice with Lewis lung carcinoma was used as a model for observing the therapeutic effect, the immunomodulatory functions, changes of quality of life, and adverse reactions of TMP. RESULTS: TMP inhibited the growth of tumor, and increased life quality and the immunity of mice with Lewis lung carcinoma. CONCLUSION: TMP have therapeutic effects in mice with Lewis lung carcinoma. Its mechanism might be associated with improving the immunity of mice with Lewis lung carcinoma.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2005年第4期421-423,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
川芎嗪
LEWIS肺癌
肺
肿瘤
tetramethylpyrazine
Lewis lung carcinoma
lung
cancer
