摘要
目的探讨新生儿足跟血TSH水平筛查作为人群碘营养状况评价指标的可行性。方法采集新生儿出生后72h的足跟血(血片),ELISA法检测促甲状腺激素(TSH);配对采集孕妇尿样及其新生儿足跟血血样,分别测定尿碘和TSH。结果随着该市人群碘营养状况的改善,新生儿TSH的总水平逐年下降(P<0.01)。2003年TSH第97百分位数(P97)为7.68mU/L,≥5mU/L的比例为16.16%;碘营养正常孕妇出生的新生儿TSH≥5mU/L比例为7.21%。结论孕妇碘营养状况是影响新生儿TSH水平的重要因素;采用ELISA法检测新生儿足跟血TSH水平以评价人群碘营养状态,切点值以TSH≥10mU/L的比例<3%较合适。
Objective To explore the possibility of using the level of neonatal heel blood thyroid stimulating hormone(TSH) as an index for iodine nutrition co ndition. Methods The TSH in heel blood cord of neonate was analyzed after 72 hours by ELISA. Heel blood of neonate was matched with urine sample of pregnant women, urine iodine and TSH was determined separately. Results Along with the improvement of iodine nutrition condition of people in the city, the overall lev el of TSH of neonate was decreased year by year(P < 0.01),but in 2003, TSH P97 w as 7.68 mU/L,accounting for 16.16% while TSH was at least 5 mU/L; 7.21% of neona tes had a TSH level higher than 5 mU/L by pregnant women with normal iodine nutr ition condition. Conclusions The iodine nutrition condition of pregnant women is an important factor to influence the TSH level of newborns,it's appropriate to set a cut-off point that less than 3% of neonates in their heel blood have a TSH level equal to or greater than 10 mU/L when iodine nutrition condition is ev aluated.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2005年第3期326-328,共3页
Chinese Jouranl of Endemiology
基金
江苏省连云港市卫生局资助项目(连卫科99009)
