Synthesis and Antibacterial Activity of 8-Substituted Phenyl-1-pyridin-3-yl-5H-bis[1,2,4]triazolo[3,4-b;4′,3′-d][1,3,4] thiadiazines 被引量：6

Synthesis and Antibacterial Activity of 8-Substituted Phenyl-1-pyridin-3-yl-5H-bis[1,2,4]triazolo[3,4-b;4′,3′-d][1,3,4] thiadiazines

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摘要 To find new structural leading compounds for the research of the multidrug resistant of antibacterial agents, five novel 8-substituted phenyl-1-pyridin-3-yl-5H-bis[1, 2, 4] triazolo[3, 4-b; 4′, 3′-d] thiadiazines were prepared from the corresponding intermediates of 3-(5-substituted phenyl[1,3,4]oxadiazol-2-ylmethylsulfanyl)-5-pyridin-3-yl-[1,2,4]triazol-4-ylamines via intramole- cular cyclization and the antibacterial activity in vitro against Gram-postive (G+) and Gram negative (G-) bacteria was primarily evaluated.

作者 GuoQiangHU SongQiangXIE WenLongHUANG HuiBinZHANG

机构地区 MedicinalCollegeofHenanUniversity ChinaPharmaceuticalUniversity

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第6期723-726,共4页 中国化学快报（英文版）

基金 supported by the National Natural Science Foundation of China(No.30070861) the Science Foundation of Henan University(XK02041).

关键词 Antibiotics TRIAZOLE THIADIAZINE SYNTHESIS antibacterial agent. Antibiotics, triazole, thiadiazine, synthesis, antibacterial agent.

分类号 O626.26 [理学—有机化学]

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参考文献9

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Chinese Chemical Letters

2005年第6期

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Synthesis and Antibacterial Activity of 8-Substituted Phenyl-1-pyridin-3-yl-5H-bis[1,2,4]triazolo[3,4-b;4′,3′-d][1,3,4] thiadiazines 被引量：6

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