摘要
目的探讨1,6-二磷酸果糖和黄芪对小儿病毒性心肌炎血清肌钙蛋白及预后的影响。方法将68例确诊为病毒性心肌炎的患儿随机分为观察组38例,对照组30例,两组均给以黄芪注射液并辅以大量维生素C,能量合剂等常规治疗,观察组加用1,6-二磷酸果糖。两组在治疗前及治疗后1周、2周分别测血清肌钙蛋白及心电图,并对心电图进行为期3个月的随访观察。结果治疗后1周、2周两组血清肌钙蛋白均较治疗前下降,但观察组下降程度明显优于对照组(分别为t=3.636,P<0.01,t=6.67,P<0.001)。治疗2周、1个月后心电图ST-T改变、室性早搏恢复例数观察组多于对照组,相比有显著性意义(χ2分别为5.71,6.42,6.41,4.50,P<0.05)。3个月复查时,ST-T改变恢复观察组仍优于对照组(χ2=5.62,P<0.05)。结论1,6-二磷酸果糖和黄芪联用能够快速降低病毒性心肌炎患儿血清肌钙蛋白,促使异常心电图恢复,改善预后。
Objective To study the effect of fructose-1,6-diphosphate (FDP) and astragalus on serum cardiac troponin I (CTnI) and prognosis in the children with viral myocarditis. Methods Sixty-eight children with viral myocarditis were randomly divided into observing group(38 cases) and control group(30 cases).Besides intravenous astragalus,vitamin C,energy mixture and so on, the children in observing group received intravenous FDP,150～250 mg/(kg·d) for 15 days.The CTnI and ECG of the children in two groups were monitored before and 1 or 2 weeks after treatment.The ECG of children was followed up three months. Results The numeric value of CTnI in two groups was decreased in 1 or 2 weeks after treatment compared with that before treatment,but there was significant difference in two groups (t=3.636,P<0.01,t=6.67,P<0.001).The ECG in observing group changed more than that in control group (χ2=5.705,6.42,6.411,4.5,P<0.05) in two weeks and one month after treatment.Three months after treatment,the number of the recovery of ST-T segment of the children in observing group was also obviously significant than that in control group (χ2=5.621,P<0.05). Conclusion Fructose-1,6-diphosphate combined astragalus can rapidly decrease the serum CTnI,promote the recovery of the ECG and improve the prognosis of the children with viral myocaditis.
出处
《实用诊断与治疗杂志》
2005年第6期403-404,406,共3页
Journal of Practical Diagnosis and Therapy
