摘要
本研究以日本大耳白兔建立实验性动脉粥样硬化模型，每天灌胃猪油１０ｇ，胆固醇１ｇ，４０ｄ后主动脉内在出现大片的粥样化斑块，切片镜检内皮细胞增生大量泡沫细胞聚积，内膜显著增厚呈典型粥样化病理改变，同时发现血脂和ＬＰＯ极度升高，ＳＯＤ活性明显降低，表明高脂血症和脂质过氧化损伤在引起动脉粥样梗化过程中是重要的因素。实验组动物每天灌胃猪油、胆固醇同时加灌刺梨汁１０ｍｌ，４０ｄ后，主动脉内膜仅有散在的点状粥样化斑块，切片病理改变较微，并可大幅度降低血脂和ＬＰＯ水平，提高ＳＯＤ活性，表明刺梨可能通过降低血脂质化氧化损伤防止动脉内膜粥样化斑块的形式。
An animal model of atherosclerosis was studied by taking 10g fat and 1g cholesterolper-day in rabbits for 40 days. The abbits had been given 10ml Rosa roxbughii Tratt for 40 days.The results showed that Rosa roxburghii Tratt could decrease aortlc atherosclerosis injury andsignificant ly reduced plasma lipd,LPO level,and significantly increse RBC-SOD activity. Theseresults suggest that Rosa roxburghii Tratt has anti-free radical lipidperoxidtion damage and anti-atherosclerosis effdcts.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1994年第9期529-532,共4页
Chinese Pharmaceutical Journal
基金
四川省卫生厅科研基金
关键词
刺梨
动脉粥样硬化
过氧化脂质
Rosa roxburghii Tratt,atherosclerosis,blood lipid,lipid peroxide,superoxidedismutase.
