摘要
本文报道４２４例癌症患者尿多胺的分析结果。各种癌症患者尿多胺含量比正常人明显增高，比正常均值增高的倍数各为：腐胺０．２２～８．１４倍，精脒０．１１～４．５０倍，精胺２．７６～１７．３１倍。本组患者一项和二项尿多胺增高者分别占总数的８８．０～１００％和６０．８７～９６．６７％。另外，在滤纸电泳图谱的腐胺和精脒色带之间又发现一条分离清晰的新色带。它在本组患者尿中均见增多，为正常均值的０．５５～３．７７倍，增高的出现率为３３．３３～１００％。笔者曾对２１例经手术和２例经化疗的癌症患者进行复查检测，其各种尿中的多胺均于治疗后下降，表明尿多胺分析可作为癌症患者辅助诊断和估计疗效的参考。
The level of urinary polyamines of 424 patients with different kinds of cancer was assayed.Results showed that urinary polyamines were significantly higher than those in normal subjects.There had been 0.22～8.14 times rise in their putrescine,0.11～4.50times rise in their spermidine,and 2.76～17.31 times increase in their spermine.Of the 424 patients,88% to 100% had a rise in one of the three polyamines;while 60.87% to 96.67%had an increase in two of the three polyamines.From the electrophoregram,a histaminelike substance was detected between their putrescine and spermidine,and its value was alsohigh,being 0.55～3.77 times higher than the normal value,with 33.33% to 100% of the patients having such a rate of elevation.For 21 cases of cancer treated with surgical operation and two cases treated with chemotherapy,reassay was made in thier urinarypolyamines.Results showed all had a reduced rate of polyamines after teatment.It can be seen that this assay can be used as useful auxiliary method in the clinical diagnosis and therapeutical evaluation of different kinds of cancers.
出处
《中国冶金工业医学杂志》
1994年第1期14-18,共5页
Chinese Medical Journal of Metallurgical industry
关键词
癌
尿多胺
分析
Cancer
Urinary polyamines
