摘要
本文采用Ｔａｔｓｕｒｏ的方法对５Ｏ例脑性瘫痪（ＣＰ）患儿外周血淋巴细胞染色体做了高分辨显带研究，发现异常核型８例。占１６％；经分组研究表明，无ＣＰ高危因素和／或家族史中癫痫ＣＰ及低智者，其染色体异常率远高于有ＣＰ高危因素而无上述家族史的ＣＰ患儿，经卡方（Ｘ２）检验有高度统计学意义（Ｐ＜０．０１），并对染色体异常与ＣＰ的相关性做了探讨；对其中２０例ＣＰ的脑ＭＲＩ改变进行了初步分析。
A
survey on children with cerebral palsy(CP)was made with high-resolution
chromosome(HRC)technique, and 8 of them were found to have abnormal karyotypes, showing
an incidence of 16%.Allabnormal karyotypes were structural aberration of autosomal
chromosome,and no sex-chromosome ab-normality was found.The incidence of abnormal
chromosome of the children without obvious risk fac-tors and/or with positive family history of
epilepsy,CP and mental retardation was different significant-ly(P<0.01).The heads of twenty
children ware examined by magnetic resonance imaging(MRI)and 16 of themwere found
abnormal. The relationship between the changement detected by MRI and clinical
menifesta-tion is discussed in the paper.
出处
《中国医科大学学报》
CAS
CSCD
1994年第1期19-22,共4页
Journal of China Medical University
关键词
脑性瘫痪
染色体
高分辨显带
cerebral palsy
high-resolution
chromosome
magnetic resonance imaging
epilepsy
mentar retardation
