摘要
用四氯化碳(CCl_4)造成大鼠肝纤维化,发现钙拮抗剂硝苯啶(Nif)明显降低早期治疗组大鼠肝纤维化肝透明质酸(HA)、羟脯氨酸(Hyp)含量及大剂量组肝N-乙酰-β-氨基葡萄糖苷酶(β-NAG)活性。晚期治疗组中,HA含量及大剂量组β-NAG,活性仍明显降低。Nif对大鼠肝纤维化肝HA、Hyp和β-NAG的影响与其剂量有一定依赖关系。实验提示Nif对CCl_4诱导的大鼠肝纤维化有抑制,甚至可能有一定逆转作用。
In early stage treatment groups,Nifedipine(Nif)could significantly reduce hepatic hyaluroic acid(HA)and hydroxyproline(Hyp)contents in rats in which liver fibrosis had been induced by CCl4 treatment.N-acetyl-β-glucosaminidase(β-NAG)activity showed a similar change in the high dosage group. In late stage treatment groups,HA was reduced markedly,and decreased β-NAG lvels were noted in the high dosage group.These effects on HA,Hyp and β-NAG were dependent on Nif dosage. The results suggest that Nif could inhibit the development of liver fibrosis in rats,and may even reverse it.
出处
《中国医学科学院学报》
CSCD
北大核心
1994年第1期35-38,共4页
Acta Academiae Medicinae Sinicae
关键词
钙拮抗剂
硝苯啶
羟脯氨酸
肝硬变
calcium antagonist nifedipine hyaluronic acid hydroxyproline N-acetyl-β-glucosaminidase