摘要
本试验将源于尸体、胎儿和甲状旁腺腺瘤的人甲状旁腺（ＰＴＧ）组织移植于９０只Ｂａｌｂ／Ｃ裸鼠的肾被膜下，成功地建立了人ＰＴＧ裸鼠过渡模型。通过对裸鼠过渡后人ＰＴＧ组织中ＨＬＡ抗原含量的动态检测发现，经裸鼠过渡１００ｄ后，人ＰＴＧ组织中ＨＬＡｃｌａｓｓⅠ抗原含量无明显改变，而ｃｌａｓｓⅡ抗原含量显著减少。作者对裸鼠过渡后三种人ＰＴＧ组织中ＨＬＡ抗原含量的变化进行了对比分析。
Human parathyroid(PTG)tissues from cadaver(C-PTG),20-28 wk fetus (F-PTG)and PTG adenoma(A-PTG) were transplanted into the kidney subcapsular spaces of Baib/C nude mice as interim host.Dynamic changes in the amount of human leukocyte antigens (HLA)in human PTG grafts within the transplantation period were observed.The results showed that during 100 days of interim hosting,no obvious changes in the amount of tissue HLA class Ⅰ antigens occurred,but the amount of tissue HLA class Ⅱ antigens were significantly reduced,The changes of HLA antigens in the different types of donor human PTG tissues were compared.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1994年第2期144-146,共3页
Acta Academiae Medicinae Sinicae
基金
国家自然科学基金
关键词
甲状旁腺
裸鼠
HLA抗原
parathyroid gland
human leukocyte antigen
nude mouse
