摘要
以丙烯酸甲酯为原料，经酰胺化反应、Ｍｉｃｈａｅｌ加成反应、氯化环合反应合成２－甲基－３（２Ｈ）－异噻唑酮及其５－氯衍生物。初步探讨了反应物配比，反应温度及时间等因素对产物收率的影响。
Methyl-3(2H )-isothiazolone and its 5-chloro derivative were synthesized from methyl acrylate by amidation, Michael addition and chlorinationcyclization.The optimum reaction conditions were disscused.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1994年第3期97-99,共3页
Chinese Journal of Pharmaceuticals
关键词
异噻唑啉酮
合成
isothiazolone,synthesis
