摘要
应用乙酰胆碱选择性微电极技术，观察到电刺激大鼠的隔内侧核（脉宽０．５ｍｓ，频率１００Ｈｚ，强度４０Ｖ），可显著提高海马ＣＡ１区乙酰胆碱的含量。赛拉嗪（２．０和６．０ｍｇ·ｋｇ－１）及咪唑克生（０．６ｍｇ·ｋｇ－１）能分别抑制或促进上述作用，而且咪唑克生可完全拮抗赛拉嗪（６．０ｍｇ·ｋｇ－１）对电刺激隔内侧核增加海马ＣＡ１区乙酰胆碱含量效应的抑制作用。结果提示，赛拉嗪具有抗胆碱作用，且其抗胆碱作用可能亦由α２－受体介导。
Using acetylcholine selective microelectrode technic, it was observed that electric stimulation of medial septal nucleus significantly increased the acetylcholine selective potential in the hippocampal CA1 region of urethane anesthetized rats. While xylazine (2.0 and 6.0 mg·kg-1)inhibited the changes of acetylcholine selective potential induced by electric stimulation of medial septal nucleus, idazoxan(0.6 mg·kg-1), the α2-adrenoceptor antagonist, significantly enhanced the changes of acetylcholine selective potential induced by electric stimulation. Idazoxan(0.6mg·kg-1) was also observed to significantly antagonise the inhibitory effect of xylazine (6.0mg·kg-1) on changes of acetylcholine selective potential in the hippocampal CA1 region induced by electric stimulation of medial septal nucleus. The results suggest a cholinolytic effect of xylazine which might be mediated by central α2-adrenoceptors.
出处
《中国应用生理学杂志》
CAS
CSCD
1994年第3期202-204,共3页
Chinese Journal of Applied Physiology
关键词
赛拉嗪
抗胆碱作用
乙酰胆碱
药理
xylazine
idazoxan
α2-adrenoceptors
cholinolytic effect
