摘要
根据骨骼肌的生理功能与脾、肝两脏密切相关的中医理论，运用疲劳与泻下因素塑造了大鼠脾气虚证模型，并采用健脾理气的中药进行治疗。对治疗前后骨骼肌中与代谢有关的ＳＤＨ、ＮＡＤＨ－ＴＲ、Ｍ－ＡＴＰａｓｅ及ＰＡＳ等进行测定的结果表明：大鼠脾气虚证模型具有骨骼肌能量代谢降低的特点，表现为Ⅰ型肌纤维有氧氧化效率的显著下降；Ⅱ型肌纤维的糖原含量锐减，糖酵解能力下降；Ｍ－ＡＴＰａｓｅ含量降低导致肌肉的兴奋收缩偶联障碍，而健脾理气药物对脾气虚导致的上述改变具有良好的恢复作用。
According to the theroy of the traditional Chinese medicine, physiological function of skeletal muscles was closely related with spleen and kidney. Rat model of insufficincy of the spleen-qi syndrom (ISQS) was developed through exercise-induced fatigue and purgation, and treated by the Chinese decoction of “invigorating the spleen and regulating the flow of qi”. Before and after the treatment, metabolism related SDH, NADH-TR, M-ATP-ase and PAS II in skeletal muscles were evaluated. The skeletal muscle were evaluated.The results showed that rat model of ISQS revealed the reduced energy metabolism in the skeletal muscle. The efficiency of aerobic oxidation in type I muscle fibers reduced significantly while the content of glucogen reduced sharply and the capacity of glucolysis decreased in type II muscle fibers. The lower content of M-ATPase induced the disturbance of muscular excitation contration coupling.The Chinese decoction of“invigorating the spleen and regulating the flow of qi”demonstrated a positive effect on the changes caused by insufficiency of the spleen-qi .
出处
《中国运动医学杂志》
CAS
CSCD
北大核心
1994年第1期28-31,共4页
Chinese Journal of Sports Medicine
关键词
健脾理气中药
骨骼肌
能量代谢
癷nvigorating the spleen and regulating the flow of qi”,insufficiency of the spleen-qi.
