摘要
从自由基角度在小鼠垂体后叶素性心肌缺血模型上探讨四逆汤保护缺血心肌的可能机制。结果表明：四逆汤可降低缺血心肌的氧自由基（ＯＦＲ）浓度和丙二醛（ＭＤＡ）含量，增加营养血流量（ＮＢＦ）和超氧化物歧化酶（ＳＯＤ）活性。提示四逆汤保护缺血心肌是通过改善缺血心肌的灌流，减轻自由基损伤反应，加强自由基防御能力等多种机制实现的。
The possible mechanisms responsible for the protective effect of Sini decoction(SND) on the ischemic myocardium were studied on the mice model of pituitrin-induced myocardial ischemia in terms of free radical.Results indicated that SND significantly decreased the concentration of oxygen free radical and the content of malondialdehyde(MDA),increased nutritional blood flow and the activity of superoxide dismutase(SOD) in ischemic myocardium.These results suggested that three mechanisms whereby SND exerted its protective effects,existedi;improving the perfusion of ischemicmyocardium,attenuating the injurious action of free radical and strengthening the free radical defense.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1994年第9期549-550,共2页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家中医药管理局重点课题
关键词
四逆汤
心肌缺血
自由基
实验
Sini decoction,myocardial ischemia,free radical
