摘要
以益气健脾、清热解毒中药治疗６２例消化性溃疡及糜烂性胃炎，观察治疗前后胃粘膜ＰＧｓ的动态变化。结果显示ＰＧＥ２治疗后与健康人接近（Ｐ＞０．０５），ＰＧＦ１α、６－ｋｅｔｏ－ＰＧＦ１α治疗后显著升高（Ｐ＜０．０１），而ＴＸＢ２较治疗前显著下降（Ｐ＜０．０１）。湿热型ＴＸＢ２较其他型显著升高（Ｐ＜０．０１）。中药对吲哚美辛诱发的大鼠实验性溃疡有明显保护作用，对ＰＧｓ的影响与临床观察一致。
The PG content were determined in 62 cases with peptic ulcer and erosive gastritis before and after the treatment of Chinese herbal drugs.The value of PGE2,PGFla,6-keto-PGFla and TXB2 were 96.25±28.51, 14.24±13.26, 10.72±9.14 and 16.51±12.24 pg/mg respectively before the treatment and were 121.42±30.02, 18.59±18.40, 18.79±12.61,8.29±6.27 pg/mg respectively after the treatment.6-keto-PGFla was significantly increased(P<0.01), TXB2 was decreased(P<0.01),but there were on significant changes in PGE2 and PGFla.Experimental study also showed that Chinese Herbal drugs played an important role in protecting indomethacine induced ulcer rats.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1994年第9期528-530,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
前列腺素
健脾益气
清热解毒
Jianpi Yiqi,Qingre Jiedu,prostaglandins,indomethacine
