摘要
目的探讨宫颈癌组织中CD44v7/8基因的异常表达及临床意义。方法1986～2000年沈阳医学院附属中心医院采用免疫组化的方法随机测定59例宫颈癌、18例尖锐湿疣和18例慢性宫颈炎组织中CD44v7/8基因的表达情况。结果宫颈癌、尖锐湿疣及慢性宫颈炎3种疾病中CD44v7/8表达阳性率分别为76.27%、11.11%和11.11%,宫颈癌组的CD44v7/8表达分别高于慢性宫颈炎组及尖锐湿疣组,且差异非常显著(P<0.01)。慢性宫颈炎组及尖锐湿疣组比较差异无显著性(P>0.05)。结论CD44v7/8蛋白的表达增强与宫颈癌的发生、发展及和局部浸润转移有关。
Objective To explore the abnormal expression of exon v7/8 in gene CD44 transcript in cervical carcinoma and its clinical significance.Methods In the central Hospital Affiliated to Shenyang Medical College from 1986 to 2002,59 patients with cervial cancer,18 patients with condyloma acuminatum and 18 patients with chronic cervicitis were detected the expression of CD44v7/8 by immunohistochemical method.Results The positive rate with expression of CD44v7/8 gene in cervical cancer,condyloma acuminatum and chronic cervicitis was 76.27%、11.11% and 11.11% respectively. It was significantly higher in cervical cancer than that in chronic cervicitis and condyloma acuminatum (P<0.01).It was not significantly different in chronic cervicitis and condyloma acuminatum.Conclusion The abnormal expression of exon CD44v7/8 is associated with the carcinogenesis,development and local invasion of cervical carcinoma.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2005年第6期369-370,共2页
Chinese Journal of Practical Gynecology and Obstetrics
