摘要
目的:研究莫达非尼对小鼠自主活动的影响,以评价莫达非尼对小鼠神经系统的作用。方法:应用计算机视频分析系统观察莫达非尼对雄性小鼠单位时间内活动的总活动度、平均速度和线性度的影响。结果: 对照组在相同时间点相比,120mg/kg的莫达非尼可以显著升高小鼠单位时间内活动的总活动度、平均速度以及线性度。60mg/kg异丙嗪可以部分拮抗莫达非尼对小鼠自主活动的影响。结论:莫达非尼可以兴奋小鼠中枢神经系统,机制可能与胆碱能系统或5-HT系统有关。
Objective:To observe the effect of modafinil on locomotor activity and on CNS in mice. Methods:Male mice were used as subjects. Total range of motion, average velocity and linearity were evaluated fay locomotion activity video analysis system. Results: Total range of motion, average velocity and linearity were significantly improved after ip 120 mg/kg Modafinil compared to saline treatment. The effect was partial antagonized by sc 60 mg/kg promethamine. Conclusion: Modafinil can stimulate CNS in mice which may involve 5-HT system.
出处
《药学实践杂志》
CAS
2005年第3期156-157,175,共3页
Journal of Pharmaceutical Practice
