摘要
目的观察泮托拉唑治疗幽门螺杆菌(Hp)相关性十二指肠溃疡的临床疗效。方法48例Hp阳性感染的十二指肠溃疡患者随机接受泮托拉唑联合羟氨苄青霉素和克拉霉素治疗或仅服用雷尼替丁治疗。4周后观察临床症状情况,并经胃镜检查观察溃疡愈合和Hp清除。结果经4周治疗发现,泮托拉唑治疗组患者明显改善临床症状(如反酸、烧心、上腹部疼痛等)并使溃疡愈合。胃窦部炎症分级明显降低,Hp也得到有效清除(P<0.05)。结论泮托拉唑联合抗Hp治疗可有效地控制十二指肠溃疡的临床症状,加速溃疡愈合,清除Hp的感染,是治疗十二指肠溃疡的一种有效、价廉的方法。
Objective To evaluate clinical effects of pantoprazole in the treatment of Helicobacter pylori (Hp) duodenal ulcer. Methods Fourth-eight patients with Hp-associated duodenal ulcer were randomly treated with pantoprazole in combination with amoxicillin and clarithromycin or with ranitidine alone. Clinical effects, inflammation changes in gastric antrum and Hp clearance were analyzed 4 weeks after systemic treatment. Results Clinical symptoms including acid regurgitation, heartburn, epigastric pain were significantly relieved after 4 week treatment with pantoprazole compared with ranitidine (P< 0.05). Pantoprazole markedly enhanced duodenal ulcer healing than ranitidine (P < 0.05). Inflammation in gastric antrum was remarkably improved (P < 0.05). Hp was also effective clearance (P < 0.001). Conclusion Pantoprazole in combination with anti-Hp therapy can effectively treat duodenal ulcer and clear Hp infection.
出处
《临床医学》
CAS
2005年第6期5-6,共2页
Clinical Medicine
