摘要
应用高温固化结合手术切除治疗肝癌曾作介绍，随访发现温免疫远位效应。为研究此种治疗方法与免疫的关系，应用小鼠移植性肝癌Ｈ２２在６５℃／６５ｍｉｎ射频条件下制备成固化瘤苗。用该瘤苗免疫小鼠（ＢＡＬＢ／Ｃ）发现能特异性主动免疫抗同源Ｈ２２３×１０＾８癌细胞的攻击，抗癌率为８６．６％，未出现瘤苗促癌生长现象。与对照组鼠比较，具有显著细胞免疫效应。认为固化瘤苗的实验有临床应用研究价值。
Attempts were made to deal with liver cancer patients in whom there was difficulty to remove the tumor by surgery. We found that the metastatic carcinoma of 4 cases in the lung disappeared in 3-6 months. As the first step coagulated tumor vaccine (CTV) was made. And,BLAB/C mice were immunized with the CTV and were attacked by giving 3 × 108 HCC after 4 weeks. The anticancer rate in immunized mouse was 86. 6%(26/30). Microscopically it was shown that cancer cells were separated and surrounded by lymphocytes and that most of the cancer cells underwent degeneration or lysis. It is suggested that the vaccine may elicit a specific active immunity to liver cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1994年第1期46-47,52,共3页
Chinese Journal of Clinical Oncology
基金
国家自然科学基金
关键词
癌
固化瘤苗
免疫学
肝肿瘤
Coagulated tumor vaccine Hyperthermia Immunity Hepatic cell carcinoma
