摘要
本文对60例肺癌和100例健康对照组用原子吸收法测定了血清锌(SZn)、铜(SCu)含量.肺癌组SZn明显低于对照组.SCu与血清铜/锌(SCu/Zn)比值明显高于健康组(P均<0.001).肺癌组按TNM分期,其SCu与SCu/Zn比值各期均较对照组明显增高,且随病期进展而增高,即Ⅳ期>Ⅲ期>Ⅱ期>Ⅰ期.SCu以1.191ppm,SCu/Zn 以1.38为分界,其特异性分别为 87%和88%;敏感性分别为 88.33%和 81.66%.较同期所测血清癌胚抗原(CEA)36.58%和肿瘤DNA聚合酶[DNA—P(CA)]18.18%为高.提示 SCu、SCu/Zn的测定是肺癌辅助诊断、疗效观察及预后判断的辅助指标.
The serum zinc,copper and Cu/Zn ratio were determined in 60 lung cancer patients and 100 healthy people from Nov. 1989 to Jan. 1992. The value of serum Zn in lung cancer group was much lower than that in the control group while the Cu and Cu/Zn ratio was much higher than that in control group (P< 0.001)and increased with escalation of disease from Stage I to IV. Taking values of Cu 1.191 ppm and Cu/Zn ratio 1. 38 as level of demarcation,the respective specificities were 87% and 88%. As compares with CEA value and DNA-P(CA) measurements of Cu,Cu/Zn ratio might contribute to the diagnosis,follow-up observation, therapeutic effect and assessment of the prognosis as well.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1994年第7期521-523,共3页
Chinese Journal of Clinical Oncology
关键词
锌
铜
比值
癌
肺肿瘤
Serum zinc Serum copper Cu/Zn ratio Lung cancer Diagnosis
