摘要
肿瘤细胞内谷胱甘肽增加与含铂类、烷化剂及含醌类等抗癌药物的耐药性有关.本文用谷胱甘肽还原酶循环法(Glutathione Reductase Recycling Assay)测定40例正常人,20例化疗前恶性肿瘤病人及20例以顺铂、环磷酰胺及阿霉素为主的化疗病人的血浆谷胱甘肽含量.化疗后病人血浆谷胱甘肽含量比正常人及化疗前者明显增高(P<0.01),而化疗前病人与正常人无显著差异(P>0.05).提示血浆谷胱甘肽增高与长期运用顺铂、环磷酰胺及阿霉素等药有关.5例临床产生耐药者血浆谷胱甘肽明显高于化疗组平均值(P<0.01),故可能与临床耐药有一定相关性.
The increment of tumor cellular glutathione(GSH)correlate with chemotherapy drugs resistance. We have measured the content of human plasma glutathione in 40 normal subjects, 20 untreated patients with malignant tumors and 20 patients under treatment with CDDP, CTX and ADR chemotherapy by glutathione reductase recycling assay. The plasma glutathione content in patients undergoing chemotherapy were significantly elevated as compared with normal subjects and untreated patients (P<0. 01). However, there were no difference between untreated patients and normal persons (P>0. 05). The mean of plasma GSH of 5 clinical drug resistance patients was higher than that of patients with chemotherapy (P<0. 01). It is suggested that the increment of the plasma glutathione content correlated with chemotherapy courses and possibly clinical drugs resistance.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1994年第10期717-719,共3页
Chinese Journal of Clinical Oncology
关键词
肿瘤
血浆
谷胱甘肽
药物疗法
癌
Malignant tumor Plasma glutathione Chemotherapy Drug resistance
