摘要
观察３０例颅脑外伤伤员血清和脑脊液中脂质过氧化物（ＬＰＯ）含量的变化，并应用大剂量地塞米松（５ｍｇ／ｋｇ）和常规剂量地塞米松（２０ｍｇ／日）进行疗效比较。结果发现，颅脑损伤后血清和脑脊液中ＬＰＯ的含量明显升高（Ｐ＜０．００１）；接受大剂量地塞米松治疗组术后第３日血清和脑脊液中ＬＰＯ的含量明显低于常规剂量治疗组（Ｐ＜０．０５），术后第３日颅内压也明显低于常规剂量组（Ｐ＜０．００１），大剂量组伤员的Ｇｌａｓｇｏｗ昏迷计分（ＧＣＳ）恢复到１５分所需的时间也明显低于常规剂量组（Ｐ＜０．０５）。提示：颅脑损伤后脂质过氧化反应增强，大剂量地塞米松能有效地抑制脂质过氧化反应，减轻脑水肿。
ipid peroxidation(LPO) in serum and cerebrospinal fluid (CSF)were measured
in 30 brain injured- patients to explore the re-lationship between LPO and pathophysiology of
traumatic brain injury (TBI).In this study, 20 patients were treated with high-dose
Dexamethesone(Dex)(5mg/kg) while the other 10 with routine-dose Dex(20mg/day). The results
demonstrated that LPOconcentrations both in serum and CSF were significantly elevated after
TBI (P<0.01).LPO in the high- dose Dex group was sig-nificantly lower than that in the
routine-dose Dex group at third day post-operation(P<0.001).LPO level in the high-dose
Dexgroup was lower than that in the routine-dose Dex cases at third day post-operation. These
results show that the lipid peroxidationmediated by oxygen free radicals was much activated
after TBI,and lipid peroxidation might participate in the pathophysiology ofTBI.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
1994年第4期157-158,共2页
Chinese Journal of Trauma
关键词
颅脑损伤
地塞米松
过氧化脂质
Traumatic brain injury Lipid peroxidation Dexamethesone
