摘要
研究了氧自由基和脂质过氧化在烧伤后免疫功能异常中的作用。结果显示，小鼠１１％～１２％总体表面积（ＴＢＳＡ）全层皮肤烧伤后第６天所测定的淋巴细胞增殖反应、白细胞介素—２生成、空斑形成细胞（ＰＦＣ）形成和迟发性超敏反应（ＤＴＨ）均处于抑制状态，血、肝、脾中过氧化脂质水平明显升高，谷胱甘肽（ＧＳＨ）含量减少；经过维生素Ｅ和ＳＯＤ处理的烧伤动物在致伤后第６天的上述免疫功能受抑制的程度明显减轻，血、肝、脾中过氧化脂质水平升高不明显，ＧＳＨ含量无明显减少。结果提示，烧伤后体内氧自由基生成增多、脂质过氧化作用亢进，可能是烧伤后免疫功能下降的原因之一。
In the present experiment, the role of free radicals and lipid
peroxidation in immune dysfunction following burn was studied.The results showed that on 6th
day after 11%-12%TBSA of full-thickness skin burn in mice, T or B-cell proliferation, interleukin-2
production, PFC formation and DTH were depressedand, the levels of lipid peroxides in
blood,liver and spleen were elevated,while the GSH content was decreased.Treatment with
vitamin E or superoxide dismutase improved the inhibition of the above im-mune functions
following thermal injury,inhibited the increase in the lipid peroxide levels and the decrease in
the GSH content ofblood, liver and spleen. It is suggested that the enhancement of free radical
production and lipid peroxidation are the causes for post-burn immune defects.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
1994年第6期268-270,共3页
Chinese Journal of Trauma
