摘要
观察沙利度胺对慢性乙型肝炎(CHB)血清细胞因子和肝功能的影响,以评价本药在CHB中的治疗价值。62例患者分2组观察,研究组29例,在一般保肝治疗基础上加用沙利度胺50mg,bid口服,连用1月;对照组33例,给予一般保肝药物治疗。结果发现CHB患者血清TNFα、IFNγ基础值显著高于健康人水平,经沙利度胺治疗后血清TNFα和IFNγ逐渐下降,IFNγ/IL-4及IFNγ/IL-10比值有升高倾向,而对照组变化不大;沙利度胺组临床症状改善较快,退黄时间和转氨酶下降速度与对照组相近。由此认为沙利度胺能调节Th1/Th2细胞因子的平衡,对病毒性肝炎有潜在的治疗价值。
To observe the effect of thalidomide on serum cytokines and liver function in patients with chronic hepatitis B (CHB) and to evaluate the therapeutic values of thalidomide for this disease.A total of 62 cases with CHB were divided into two groups,group A(thalidomide treated group) were given thalidomide 50mg bid,in addition to symptomatic therapy,group B(control group) were given Yinzhihuang、PGE1 and other symptomatic treatment.It was found that in thalidomide treated patients serum tumor necrosis factor α (TNFα)and interferon-γ (IFNγ) gradually decreased with increasing IFN γ/IL-4 and IFN γ/IL-10 ratios when compared with control group.Meanwhile the clinical symptoms in thalidomide group improved faster,and the improvement of liver function was comparable with control group.From these data we conclude that thalidomide is able to modulate the Th1/Th2 balance and may have the potential value to treat viral hepatitis.
出处
《临床肝胆病杂志》
CAS
2005年第3期153-155,共3页
Journal of Clinical Hepatology
