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低剂量辐射诱导免疫适应性反应的最佳时间 被引量:9

Optimal time interval for induction of immunologic adaptive response.
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摘要 本实验观察了低剂量X射线全身单次照射诱导昆明小鼠免疫适应性反应的最佳时间.证实当预照射剂量(D_1剂量)为75mGy.剂量率12.5mGy/min,损伤剂量(D_2剂量)为1.5Gy,剂量率0.33Gy/min,D_1与D_2间隔6h可诱导脾细胞对脂多糖反应的适应性反应,D_1与D_2间隔12h可诱导胸腺细胞自发增殖及脾细胞对ConA及脂多糖反应的适应性反应.以上结果表明,当D_2为1.5Gy时。75mGy诱导上述免疫适应性反应的最佳时间间隔为6h及12h. The optimal time interval between prior dose (DI ) and challengedose (DZ ) for the induction ofimmunologic adaptive response wasinvestigated' Kunming mice were exposed tO 75 AGe X^rays'at a dose rateof i2'5 mGy/min'3, 6. 12, 24. or 60h after the prior irradiatioll the micewere challenged with a dose of 1'5Gy at a dose rate of 0' 33 Gy/min. 18hafter DZ,the mice were sacrificed forexamination of imrnunological parameters. The results showed that withan interval of 6 h between DI andD2, the adaptive. response of thereaction of splenocytes to LPS wasinduced, and with an interval of 12hthe adaptive re$ponses of spontaneous incorporation of sH--TdR intothymocytes and the reaction of splenocytes to Con A and LPS were induced with 75. AGe:prior irradiation.Our data suggested that the optimaltime intervals between DI and DZfor the induction of immunologicadaptiye response were G h and 12 hwith a DI of 75 mGy and a DZ of1 '5 Gy' The mechanism of itnmunologic adaptation following foxy doseradiation is discussed'
出处 《中华放射医学与防护杂志》 CAS CSCD 北大核心 1994年第5期311-313,共3页 Chinese Journal of Radiological Medicine and Protection
基金 国家自然科学基金
关键词 低剂量辐射 免疫 适应性反应 low dose radiation immunologic adaptive response optimal time interval
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  • 1蔡露,动物学杂志,1988年,23卷,4期,11页
  • 2蔡露,中华放射医学与防护杂志,1988年,8卷,3期,191页
  • 3刘树铮,Health Physics,1987年,52卷,579页
  • 4刘树铮,中华放射医学与防护杂志,1987年,7卷,4期,241页
  • 5刘伟宏,中华放射医学与防护杂志,1987年,7卷,5期,336页
  • 6刘伟宏,中华放射医学与防护杂志,1986年,6卷,2期,77页
  • 7杨宝辰,中华医学检验杂志,1984年,7卷,3期,149页
  • 8赵勇,龚守良,刘树铮.低剂量电离辐射诱导免疫适应性反应的时间效应[J]白求恩医科大学学报,1995(05).

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