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钒取代磷钨酸VO(phen)_2^(2+)配合物的合成、表征及生物活性 被引量:2

Synthesis, characterization and biological activity of vanadium substituted heteropoly acidVO(phen)_2^(2+) complexes
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摘要  合成了2个V取代磷钨酸邻菲咯啉氧钒配合物.采用元素分析、红外光谱、51VNMR、31PMASNMR等手段对配合物的结构进行了表征.并对化合物进行了肝肿瘤细胞的抑制作用研究.结果表明,磷钨酸中的W被V取代后与邻菲咯啉氧钒配离子形成了氧钒配合物,该配合物对肝肿瘤细胞SMMC-7721具有较强的体外抑制作用. <Abstrcat>Two vanadium substituted heteropoly acid VO(phen)(2+)(2) complexes have been synthesized and characterized with elemental analysis, IR,(51)V NMR and (31) P MAS NMR,The results shown that vanadium substituted heteropoly acid only combine with one VO(phen)(2+)2, and may be have connected with reaction condition and space factor. The result shows that the compound has higher biological activity to SMMC-7721 cancer cell in vitro in the condition.
出处 《东北师大学报(自然科学版)》 CAS CSCD 北大核心 2005年第2期55-58,共4页 Journal of Northeast Normal University(Natural Science Edition)
基金 国家自然科学基金资助项目(20171011)
关键词 磷钨酸 邻菲咯啉 氧钒配合物 生物活性 肿瘤细胞 heteropoly acid 1,10-phenanthroline oxovanadium complex biological activity tumor cell
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参考文献12

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