摘要
目的探讨碘摄入量和甲状腺功能障碍之间的关系。方法对轻度碘缺乏、碘超足量、碘过量三个碘摄入水平地区14岁以上成年人的流行病学调查资料进行多因素分析。结果Logistic回归显示,碘超足量、碘过量是亚临床甲减和临床甲减的独立危险因素(P<0.05)。碘过量时亚临床甲亢的患病危险减少,OR值为0.218(P<0.05)。引入碘摄入量与甲状腺自身抗体的交互作用后,碘过量仍然是亚临床甲减和临床甲减的独立危险因素(P<0.01);碘超足量对临床甲减无显著影响,但使亚临床甲减的患病危险性显著升高(P<0.01),并且其与TgAb的联合作用显著升高亚临床甲减和临床甲减的患病危险性(P<0.05)。结论碘摄入量增加有抑制甲状腺功能的趋势,碘超足量和碘过量使甲状腺功能减退症患病危险增加。
[Objective]To assess the relationship between iodine intake and thyroid dysfunctions. Logistic regression model was used to analyze the risk factors of hypothyroidism and hyperthyroidism, according to the epidemiologic data of 3762 adults in 3 rural areas with different iodine intake: mild deficient iodine, more than adequate iodine and excessive iodine. More than adequate iodine and excessive iodine were independent risk factors of subclinical and overt hypothyroidism (P <0.05). Excessive iodine decreased the risk of subclinical hyperthyroidism. When interactions of iodine intake and TPOAb, TgAb were included, more than adequate iodine was a risk factor of subclinical hypothyroidism, but had no such effect on overt hypothyroidism. Interaction of more than adequate and TgAb significantly affected subclinical and overt hypothyroidism (P <0.05). [Conclusion] Increase of iodine intake tends to inhibit thyroid function. More than adequate iodine and excessive iodine are independent risk factors of hypothyroidism. The risk of hypothyroidism grows up and the inhibition of thyroid function becomes more serious with the inreasement of iodine intake.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2005年第9期1285-1288,共4页
China Journal of Modern Medicine
