摘要
氟骨症骨转换加速 ,骨代谢异常。用成骨细胞分泌的酶如骨碱性磷酸酶、骨钙素等骨代谢生化标志物评估骨形成 ,用破骨细胞分泌的酶如抗酒石酸酸性磷酸酶及骨吸收中形成的代谢产物如尿羟脯氨酸等生化标志物评估骨吸收。
The metabolism of bone is reflected by biochemical markers of bone's resorption, formation and bone turnover. Skeletal fluorosis is characterized by accelerated bone turnover and bone metabolism's disorder. Bone formation markers indicate osteoblast activity: Bone Alkaline Phosphatase which produced by osteoblast is an excellent indicator of bone formation.Osteocalcin, bone Morphogenetic Protein and Procollagen I Carboxyterminal Propeptide are also considerated as some other important markers of osteoblast activity; Markers of resorption represent osteoclast activity: Tartrate Resistant Acid Phosphatase excreted by osteoclast plays an important role in the bone resorption process. Hydroxyproline measurement can also be used as an index of osteoclast's metabolic activity. In conclusion,bone metabolism biochemical markers provide new and potentially important tools for the study of skeletal fluorosis.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2003年第2期186-188,共3页
Chinese Jouranl of Endemiology
