摘要
综述了近8年来液相组合合成中小分子化合物库的纯化方法,如通过固载化试剂的应用、可溶性聚载物的应用、氟合成技术、液相萃取等达到纯化目的。论述了这些纯化方法的基本原理、使用范围及局限,并列举了一些经典实例。
Purification strategies of small molecular compound libraries in solution phase combinatorial chemistry during the past eight years are summarized in this paper.Those popularized methods of purification included:application of solid-phase bound reagents,synthesis of soluble polymer supports,purification by fluorous synthesis,and so on.Their principles,application areas and defaults were involved.Some typical and novel examples on purification of compound libraries in solution phase combinatorial chemistry were given.
出处
《化学试剂》
CAS
CSCD
北大核心
2005年第5期271-275,共5页
Chemical Reagents
基金
国家自然科学基金资助项目(20372021)
湖南省自然科学基金资助项目(03JJY3018)。
关键词
液相组合合成
化合物库
纯化
固载化
氟合成
清除树脂
solution phase combinatorial chemistry
combinatorial library
purification
solid-phase bound reagent
fluorous synthesis
scavenger resin
