摘要
目的:探讨药物性肝病(DILD)的病因、临床特点及发病规律,以提高临床医师对该病的认识。方法:回顾性分析本院1999年1月至2004年12月收治的242例DILD患者的资料。结果:引起DILD的药物种类多,临床多以急性或亚急性起病,主要表现为乏力、恶心、呕吐、尿黄、身目黄染及肝大等。肝功能指标除ALT、AST及TB升高外,GGT及ALP也明显升高,且较ALT、AST及TB恢复慢。部分合并多脏器功能衰竭。治疗后83.9%治愈或好转,8.7%无变化或加重,7.4%死亡。结论:DILD涉及药物种类多,临床表现无特异性;但病死率较高,应引起重视。
Objective: By analyzing the etiology, clinical features and characters of drug,induced liver damage (DILD) to improve the understanding of the disease. Methods: 242 cases of DILD admitted from Jan, 1999 to Dec, 2004 were retrospectively analyzed. Results: A variety of drugs can cause DILD. Most of the cases showed an acute or sub acute onset with the main clinical features of enervation, nausea, vomiting, yellowish urine, and jaundice and enlarged liver. Liver function damage was featured by elevation of serum ALT, AST, GGT, ALP, TB. There is marked elevation of GGT and ALP and this frequently indicates a slower recovery than ALT, AST and TB. Part of the patients was complicated with multiple organs failure. 83.9% of the cases were cured or improved, 8.7% showed no changes and 7.4% died. Conclusions: DILD are induced by a variety of drugs. The clinical features are no specificity and high mortality and should be attended.
出处
《岭南急诊医学杂志》
2005年第2期108-110,共3页
Lingnan Journal of Emergency Medicine
关键词
药物性肝病
临床分析
治疗
诊断
drug,induced liver damage
clinical features
Meta,analysis
