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膀胱癌P_(53)过度表达的临床意义 被引量:5

The clinical significance of expression of P53 gene in human bladder cancer
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摘要 通过免疫组化ABC法,对50例手术切除或活检的膀胱癌标本石蜡切片进行P_(53)基因表达的研究。结果表明:膀胱P_(53)蛋白过度表达率为42%(21/50),其中PT_240%(12/30),PT_382%(9/11),PT_a,PT_1为0;G_232%(8/25),G_372%(13/17),G_1为0。随访25例患者,13例P_(53)阳性过度表达,其中有76%(10/13)有复发转移,而单纯复发者只占23%(3/13)。13例P_(53)阳性表达者平均存活时间22.6个月/例,12例P_(53)阴性表达者平均存活63.7个月/例。P<0.01。 Mutation in the gene coding for p53 tumour suppressor protein has been common in a variety of human cancer. To assess the role of a putative mutated p53 protein in human bladder cancer,a monoclonal antibody technigue was used in an immunoperoxidase detection system. A total 50 bladder cancer cases were studide 49 being transitional cell carcinomas and the remaining one squamous cell caricinoma.p53 position nuclear staining was found in 21 of 50 bladder cancer (42%),including 9 of 11 cancer with PT3, 12 of 30 cancers with PT2,13 of 17 bladder cancers with Grade 3 and 8 of 25 bladder cancers with grade 2.p53 position nulear staining was not obseved in any of 9 cancers with PTA PT1 and neither in grade 1 cancers 8.A total of 25 patients have been followuped , 10 of 13 cases having p53 position nuclear staining were found to have metasteses(76.9%).The mean survival time was compared between cases, cases with positire,p53 position nucles staining had a statistically significant poor prognostic value.(P<0. 01)
出处 《中华泌尿外科杂志》 CAS CSCD 北大核心 1994年第2期113-115,共3页 Chinese Journal of Urology
关键词 膀胱肿瘤 免疫组织化学 Bladder neoplasms Carcinoma Genes Immunity Histocytochemistry
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