摘要
将犬的膀胱与尿道离断，实验发现乙酰胆碱导致膀胱、尿道收缩。前者被阿托品对抗，后者只能被酚妥拉明阻断。α－肾上腺素能制剂对膀胱无影响，但去甲肾上腺素升高尿道压，酚妥拉明降低尿道压。异丙肾上腺素使膀胱活动下降，但对尿道无作用。实验结果表明，在体内胆碱能药物、β－肾上腺素能药物对膀胱作用明显；α－肾上腺素能药物对尿道的作用十分显著。乙酰胆碱间接兴奋α－受体致使尿道阻力增加。
The canine urethra was completely severed from the bladder neck.It was shown that Ach promoted contraction of the bladder body and urethra.The former effect was blocked by atropine,while the latter was antagozied with phentolamine.Although a-adrenergic drugshad no influence on the bladder,yet norepinephrine induced a rise in urethral pressure and phentolamine reduced the urethral pressure,Isoproterenol had little effect on the urethra, but caused a reduction of bladder activity.Our results demonstrated that cholinergic and β-adrenergic agents had significant influence on the in vivo bladder body,and a-adrenergic drug showed great effects on the in vivo urethra.Ach caused a elevation in the urethral pressure through indirect activation of the a-receptors in the urethral musculature.The clinical significance related to the present investigation was disscused.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1994年第5期373-375,共3页
Chinese Journal of Urology
