摘要
目的探讨牛磺酸对化学性急性呼吸窘迫综合征(ARDS)的防治作用及可能机制。方法经股静脉注射油酸复制大鼠ARDS模型,应用电子自旋共振(ESR)技术观察大鼠肺内活性氧(ROS)自由基的生成情况,观察血浆丙二醛(MDA)含量和超氧化物歧化酶(SOD)活力的变化,进行肺湿干重、肺系数测定及肺组织病理学检查。结果牛磺酸组大鼠肺湿干重、肺系数及病理学指标皆得到显著改善,并且高剂量用药效果更佳。研究显示牛磺酸可显著降低ARDS大鼠肺内ROS含量,抑制组织脂质过氧化的发生,提高SOD活力。结论牛磺酸对化学性ARDS具有防治作用,其机制之一与减少体内活性氧自由基的生成有关。
Objective To explore the possible mechanism of taurine for its preventive and therapeutic effects on acute respiratory distress syndrome (ARDS). Methods A rat model of ARDS was produced by femoral vein injection of oleic acid. Electron spin resonance (ESR) technique was used to measure reactive oxygen species (ROS) in lung tissue. Plasma malondialdehyde (MDA) contents and superoxide dismutase (SOD) activity as well as other indexes were studied. Results Taurine could effectively decrease the production of ROS in lungs of ARDS rats. The activity of SOD and pathological indexes were all improved in taurine groups compared with ARDS rats. Effects were better in the high dose taurine group. Conclusion Preventive and therapeutic effects of taurine on ARDS might be related to the decreasing of ROS production.
出处
《中国职业医学》
CAS
北大核心
2005年第3期2-4,共3页
China Occupational Medicine
基金
国家自然科学基金课题(30170799)
国家教育部博士点基金课题(20010001092)
关键词
牛磺酸
急性呼吸窘迫综合征
活性氧
电子自旋共振
Taurine
Acute respiratory distress syndrome (ARDS)
Reactive oxygen species (ROS)
Electron spin resonance (ESR)
