摘要
目的:分析鼻咽癌(NPC)患者放疗前后鼻窦炎发生的影响因素,并探讨防治放疗后继发鼻窦炎的措施和手段。方法:回顾性统计分析231例NPC患者放疗前后发生鼻窦炎的影响因素及部分患者的治疗效果。结果:231例NPC患者中,放疗前98例患有鼻窦炎,放疗后165例发生鼻窦炎,其中T分期较高、鼻腔有解剖变异的患者放疗后鼻窦炎发生率较高,有鼻咽局部治疗的患者鼻窦炎发生率较低,放疗前就有鼻窦炎的患者,绝大部分患者放疗后不仅没有得到改善反而有所加重。结论:放疗前鼻窦炎的发病率随临床分期的加重而递增,窦口鼻道复合体的解剖变异、鼻腔解剖变异仍然是其发生的重要因素。对于放射治疗的NPC患者,T分期较高、解剖变异、鼻咽局部治疗以及放疗状况与放疗后鼻窦炎的发生有关,加强放疗前鼻窦炎的治疗以及放疗中、后期鼻咽局部治疗可减少放疗后鼻窦炎的发生。
Objective:To study the risk factors and preventive steps of nasosinusitis after radiotherapy of nasopharyngeal carcinoma(NPC).Method:Two hundreds and thirtyone NPC patients were retrospectively analysed.Result:Among 231 NPC patients,98 patients(42.4%)had nasosinusitis before radiotherapy,165 patients(66.7%)suffered from nasosinusitis after radiotherapy. The rate of nasosinusitis in NPC patients with high T stage and nasalcavity anatomical aberrance was higher than in others (P=0.014,OR=1.973;P=0.034,OR=2.156), and the rate of nasosinusitis in NPC patients with nasopharynx therapy was low(P=0.008,OR=0.675), most patients with nasosinusitis before radiotherapy had not any improve after radiotherapy,and effected the effect of radiotherapy.Conclusion:To reduce nasosinusitis after radiotherapy and improve patients quality of life, we suggest that nasopharyngeal cavity therapy should be carried out during and after irradiation for NPC patients, especially for those patients with high T stage and nasalcavity anatomical aberrance, and for those who had nasosinusitis before radiotherapy.
出处
《临床耳鼻咽喉科杂志》
CAS
CSCD
北大核心
2005年第12期554-556,共3页
Journal of Clinical Otorhinolaryngology
基金
2003年度广东省中医药局科研课题基金资助项目(No:403014)
关键词
鼻咽肿瘤
放射疗法
鼻窦炎
Nsaopharyngeal neoplasms
Radiotherapy
Nasosinusitis
