摘要
采取４例处缓解期的普通型急性淋巴细胞白血病患者的骨髓，用补体介导细胞毒法体外净化后进行自体骨髓移植，其中３例分别于移植后４２、３５和１２个月仍处于完全缓解；１例移植后４个月复发。对另外３例经化疗达完全缓解的未分化型（２例）和普通型（１例）急性淋巴细胞白血病患者采取骨髓，用免疫毒素法体外净化后行自体骨髓移植，２例分别于移植后１４和６个月仍处于完全缓解，１例移植后５个月，因患急性重型肝炎死亡，但骨髓仍为完全缓解。体外净化所用的单克隆抗体为ＭｃＡｂ５５、ＪＮ２０５及ＰＨＮ２００。
ABMTs on 4 cases of common-ALL in remission were studied. The bone marrow was purified in vitro by complement mediated cytotoxicity. Three of them remained in complete remission after 42, 35, and 12 months respectively, and one relapsed after 4 month remission. The bone marrow of other 2 cases of Null-ALL and one case of common-ALL was purified in vitro by immunotoxin after their complete remission, and then they were treated by ABMT. Two of them remained in complete remission after 14 and 6 months respectively and one, after 5 months of remission, died of fulminant hepatitis.
出处
《中华器官移植杂志》
CAS
CSCD
1994年第3期128-130,共3页
Chinese Journal of Organ Transplantation
关键词
白血病
单克隆抗体
净化
骨髓移植
Acute lymphoblastic leukemia (ALL) Monoclonal antibody (McAb)
Immunotoxin
Purified in vitro
Autologous bone marrow transplantation (ABMT)
