摘要
目的研究克鼻敏汤治疗变应性鼻炎的机制。方法60例变应性鼻炎(allergicrhinitis,AR)患者随机分为克鼻敏汤治疗组(治疗组)和辛芳鼻炎胶囊对照组(对照组)进行治疗,观察两组疗效;采用酶联免疫吸附法(ELISA)对两组治疗前、后血清黏附分子(sICAM-1、P-选择素),Th1细胞因子(IFN-γ、IL-2)和Th2细胞因子(IL-4、IL-5)进行了检测;并与健康对照组进行比较。结果治疗组及对照组血清黏附分子和Th2细胞因子水平明显高于健康对照组(P<0.01),Th1细胞因子水平低于健康对照组(P<0.01);治疗后治疗组血清黏附分子和Th2细胞因子水平较治疗前明显下降(P<0.01);Th1细胞因子水平较治疗前明显增高(P<0.01),而对照组较治疗前无明显变化(P>0.05)。结论克鼻敏汤通过抑制血清黏附分子的产生和调节Th1和Th2细胞因子的表达,纠正失衡的Th1/Th2的细胞因子网络而对变应性鼻炎产生治疗作用。
ObjectiveTo investigate the mechanisms of Kebimin decoction (KD) in treating allergic rhinitis (AR). MethodsSixty patients with AR were randomly divided into two groups, patients in the treated group (TG) were treated with KD, those in the control group (CG) were given Xinfang rhinitis capsule. The serum levels of adhesion molecule (sICAM-1, P-selectin) , Th1 cytokines, including interferon-γ (IFN-γ) and interleukin-2(IL-2), and Th2 cytokines (IL-4 and IL-5) were determined by enzyme-linked immunosorbent assay(ELISA) before and after treatment, and compared with those in 30 healthy subjects as control. ResultsThe serum levels of adhesion molecule and Th2 cytokines were higher and Th1 cytokines were lower in AR patients than those in healthy control (P<0.01). After treatment, these indexes were restored significantly ( P<0.01) in the treated group, but no significant change was found in the control group. ConclusionKD has definite effect in treating allergic rhinitis by inhibiting production of adhesion molecule and regulating the levels of Th1/Th2 cytokines to correct the imbalanced Th1/Th2 cytokines network.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2005年第6期505-507,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
广东省湛江市科委攻关课题(No.2001-85)
