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吡喹酮固体分散体泡腾片的制备 被引量:5

Preparation of the Solid Dispersion-Effervescent Tablets of Praziquantel
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摘要 为提高吡喹酮的生物利用度,制备了吡喹酮固体分散体泡腾片。采用熔融法制备吡喹酮固体分散体,经差示扫描量热法及红外光谱法对其进行分析。采用正交试验L8(27)对泡腾片制备处方进行筛选与优化。对吡喹酮固体分散体泡腾片进行含量和回收率的测定,并对片剂进行质量检查。结果表明,吡喹酮制备成固体分散体。正交试验方差分析结果表明润湿剂对泡腾片的崩解时间影响显著。吡喹酮标准曲线为A=1.153×C+7.297×10-3,r=0.9998。吡喹酮泡腾片剂的平均回收率为93.27%,RSD为1.90%,平均含量为97.32%,RSD为0.71%。泡腾片剂经质量检查合格。 To improve the relative bioavailability of praziquantel, prepared praziquantel solid dispersion-effervescent tablets. Methods: praziquantel solid dispersion was prepared by melting method, and examined using differential scanning calorimetry (DSC) and infrared spectrometry (IR). In order to determine the better preparation formulation of effervescent tablets, an orthogonal experiment design L8(27) was arranged. The average recovery and content were examined. The quality examination on effervescent tablets was made. Results: Praziquantel were prepared solid dispersion. Variance analyses indicated: the moistening agents had significant influence on disintegrated time. Praziquantel standard curve regression equation was A=1.153×C+7.297×10-3, r=0.9998.The average recovery of praziquantel was 93.27%, RSD was 1.9%, the average content was 97.32%, RSD 0.71%. The quality-examination result was qualified.
出处 《中国农学通报》 CSCD 2005年第6期5-7,共3页 Chinese Agricultural Science Bulletin
基金 国家"十五"科技公关项目(2001BA606A)
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