摘要
我们用尿白介素6(IL-6)依赖细胞株7TD_1细胞,测定了21例原发性IgA肾病(IgAN)患者尿和血清IL-6活性水平,并分析了IL-6活性水平与IgAN临床及病理改变的联系。结果:IgAN患者尿及血清IL-6与活性均增高(活性增高者分别占46.7%及25%),尿IL-6与血清IL-6水平无平行关系。尿IL-6活性水平与IgAN严重蛋白尿的发生以及肾小球病变(节段肾小球硬化、新月体、系膜扩张等)和小管一间质病变程度呈正相关。因而尿IL-6测定对IgAN的临床分析具有十分重要的意义。
Cytokines may play an important role in the development of IgA Nephropathy(IgAN). In this study, the levels of Interleukin—6(IL—6)activity in the urine and serum from 21 patients with IgAN were measured by using IL—6 dependent cell line, 7TD. IL—6 activities were detectable in both urine and serum in patients with IgAN(IL—6 detectable rate 47.6% and 25% respectively), while it was undetectable in normal volunteers. There was no correlationship between urinary and serum IL—6 activities. Also, we found that patients with elevated urinary IL—6 activity had heavy proteinuria and severe glomerular and tubular—interstitial histological changes. The results suggest that the measurement of IL—6 is useful in evaluating the degree of glomerular and interstitial damage in patients with IgAN.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1994年第4期201-203,共3页
Chinese Journal of Nephrology
