摘要
用间接免疫荧光法、酶联免疫吸附试验（ＥＬＩＳＡ）及ＬＤＨ释法，对１６例急性输血后丙型肝炎（抗－ＨＣＶ、ＨＣＶ－ＲＮＡ均阳性）患者，分别进行外周血单个核细胞（ＰＢＭＣ）的Ｔ细胞亚群计数、Ｔ４／Ｔ８比值、Ｔａｃ受体的检测及血清可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）ＮＫ细胞活性的测定。并与正常人组比较，经ｔ检验发现，急性丙型肝炎患者的Ｔ４亚群所占百分比、Ｔ４／Ｔ８比值及ＰＢＭＣＴａｃ受体表达均明显低于正常人组（Ｐ＜０．０５），而ＮＫ细胞活性、血清ｓＩＬ－２Ｒ明显高于正常人组（Ｐ＜０．０５）。患者的这些免疫状态改变，可能对其发病机理的研究有一定意义。
Sixteen patients with acute hepatitis C were detected for the percentage of T subpopulation, the ratio of T4 and T8, the expression of IL-2R in PBMC (Tac recepteor), the soluble IL-2R (sIL-2R) in serum, and the activity of NK cells. Comparing of normal group with patients, the results showed that the percentage of T4/T8 ratio and the expression of Tac reduced significantly (P<0.05). But the activity of NK cells and the sIL-2R level in serum increased significantly (P<0.05).These immune changes in patients with acute hepatitis C may be of help for research on pathogenesies of acute hepatitis C.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
1994年第1期35-37,共3页
Chinese Journal of Experimental and Clinical Virology
关键词
急性
丙型肝炎
免疫学
Acute hepatitis C
T_4/T_8 rate
IL-2R
sIL-2R
