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维甲酸对大鼠实验性腺胃粘膜癌前病变的逆转治疗作用 被引量:12

THERAPEUTICEFFECTSOFRETINOlCACIDONEXPERI- MENTALLYINDUCEDPRECANCEROUSLESIONSOFTHE GLANDULARGASTRICMUCOSAINWISTARRATS
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摘要 本文旨在观察维甲酸对大鼠胃粘膜癌前病变的作用,结果示,维甲酸治疗组大鼠腺胃粘膜上皮化生、中重度异型增生和胃癌的发生率(72.0%、24.0%、0%)均显著地低于未加治疗的对照组(100.0%、52.0的、16.0%)(P<0.01、P<0.05);治疗组大鼠幽门腺和胃底腺平均肠化腺体数(130.2±93.9、51.5±39.1)及硫酸粘液阳性肠化发生率(36.0%)亦显著地低于未加治疗的对照组(442.4±230.0、247.4±112.0,84.0%)(P<0.01),本实验中未观察到维甲酸明显的毒副作用,说明维甲酸对大鼠实验性腺胃粘膜癌前病变有良好的治疗作用;这为探讨人胃癌前病变的治疗提供了新途径。 he therapeutic effects of retinoic acid(RA)on experimentally induced precancerouslesions of the glandular gastric mucosa in Wistra rats were studied. Intestinal metaplasia(IM)anddysplasia in glandular stomach of rats were induced by giving both 003%ranitidinein diet and 50μg/ml N-m ethyl- N’-n itro- N-nitrosoguanidine(MNNG) in drinking water adlibitum for 20 weeks. From the beginning of the 36th week, RA(40mg/kg.body weight/day)was administered to rats of the treated group for 8 weeks and subsequently rats were killed。Results showed that the incidences of IM (72.0%), moderate and severe dysplasia (24.0%)andgastric cancer(0%)and the numbers of metaplastic glands in both the pyloric and fundicgland mucosa(130.2 ± 93.9, 51.5 ± 39.1) were significantly lower in RA treated group than inuntreated group(100.0%, 52.O%,16.0%,442.4± 230.0,247.4± 112.0 respectively) (P<0.0l andP<0.05).There was also significant difference(P<0.01) in the incidence of sulfomucinpositive IM between the RA treated group(36.0%)and untreated group (84.0%).Obvious sideeffects of RA were not observed.It is therefore concluded that RA is an effective therapeuticagent for the precancerous lesions of glandular gastric mucosa in Wistar rats。
出处 《中华消化杂志》 CAS CSCD 北大核心 1994年第6期319-321,共3页 Chinese Journal of Digestion
关键词 胃粘膜 癌前病变 维甲酸 药物疗法 Gastric mucosa Precancerous lesions Retinoid acid。
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参考文献4

  • 1李春启,1992年
  • 2团体著者,胃及十二指肠粘膜活检病理,1980年
  • 3蔡海英,肿瘤防治研究,1978年,4卷,12页
  • 4张椿年,国外医学参考资料药学分册,1974年,6卷,359页

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