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结核分枝杆菌调控巨噬细胞凋亡机理的研究进展 被引量：9

Advance in studies of mechanism of mycobacterium tuberculosis-induced macrophage apoptosis
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摘要 综述了结核分枝杆菌感染机体后,巨噬细胞凋亡的正、反向调控机制。在感染早期,结核分枝杆菌可以激活caspase酶系,引发一系列级联反应,在细胞因子IL1β、TNFα的作用下,激发信号转导途径。胞内线粒体发生一系列结构和功能的变化,释放凋亡诱导因子。一系列因子协同作用,最终启动巨噬细胞凋亡,并导致细菌被杀灭。同时,结核分枝杆菌某些菌体成分可被巨噬细胞表面特异性受体识别,抑制巨噬细胞中分泌细胞因子的生物学活性,从而减少凋亡。结核杆菌通过一系列调控机制,以休眠状态存活于巨噬细胞中,与宿主达成一种动态平衡。
作者 陈思静 卢贤瑜
机构地区 重庆医科大学临床免疫教研室
出处 《国外医学（临床生物化学与检验学分册）》 2005年第5期276-278,共3页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
关键词 结核分枝杆菌 巨噬细胞 细胞凋亡 研究进展
分类号 R52 [医药卫生—内科学]
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参考文献16

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同被引文献81

  • 1王巧莲.铁代谢检测指标与检测方法[J].中国医药导报,2005,2(17):111-112. 被引量：8
  • 2夏飞,刘胜武,魏雅稚,肖凌.结核分枝杆菌诱导宿主巨噬细胞凋亡机制初探[J].中华微生物学和免疫学杂志,2005,25(6):463-468. 被引量：7
  • 3陶昆(综述),卢贤瑜(审校).肿瘤坏死因子-α抗结核免疫作用研究进展[J].国际检验医学杂志,2006,27(2):143-145. 被引量：16
  • 4吕志敢,郭政.肿瘤坏死因子的研究进展[J].山西医科大学学报,2006,37(3):311-314. 被引量：78
  • 5Canetti G.Present aspects of bacterial resistance in tuberculosis.Am Rev Respir Dis,1965,92:687-703.
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  • 9Riendeau CJ,Kornfeld H.THP-1 cell apoptosis in response to Mycobacterial infection.Infect Immun,2003,71:254-259.
  • 10Oddo M,Renno T,Attinger A,et al.Fas ligand-induced apoptosis of infected human macrophages reduces the viability of intracellular Mycobacterium tuberculosis.J Immunol,1998,160:5448-5454.

引证文献9

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国外医学（临床生物化学与检验学分册）
2005年 第5期

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