摘要
目的探讨螺内酯对高血压病患者血管内皮细胞功能的影响。方法选择52例高血压病患者作为试验组,30例健康者作为对照组,给药前先测定试验组和对照组的内皮素(ET)、血栓素A2(TXA2)、一氧化氮(NO)、前列环素(PGI2),再予以试验组螺内酯20mg/d,3个月后再测定试验组的患者ET、TXA2、NO、PGI2并进行比较。结果给药前试验组患者的ET、TXA2水平显著高于对照组,NO、PGI2水平显著低于对照组;给药后试验组患者ET、TXA2较给药前明显降低,而NO、PGI2水平较给药前明显升高。结论螺内酯可以有效地改善血管内皮细胞功能,对逆转高血压病患者血管内皮细胞功能紊乱起重要的作用。
Objective To study the effect of antisterone on the function of endothelial cell. Methods 52 patients with hypertention were selected in experiment group and 30 healthy people as a control group.ET,TXA_2,NO,PGI_2 levels were tested in both groups.Then antisterone 20 mg were taken once a day in expeniment group,and all the indexes after 3 months were tested. Results Before taking antisterone,ET and TXA_2 levels of experiment group were higher than that of control group,but NO and PGI_2 were lower.After taking antisterone,NO and PGI_2 levels were significantly increased and ET and TXA_2 levels were significantly decreased. Conclusion Antisterone can effectively improve the function of blood vessel endothelial cell,and plays an important role reversing the dysfunction of endothelial cell in hypertention.
出处
《白求恩军医学院学报》
2005年第2期72-74,共3页
Journal of Bethune Military Medical College
关键词
高血压病
螺内酯
内皮细胞
Hypertention
Antisterone
Edothelial cell
