摘要
目的 研究整合素αVβ3在人胆管癌组织中的表达及其与胆管癌的临床病理关系。方法 采用免疫组织化学方法检测47例人胆管癌组织及正常癌旁胆管组织中整合素αVβ3的表达。结果 整合素αVβ3表达于人胆管癌细胞及胆管癌组织中的新生血管细胞,47例标本均呈阳性表达,其表达强度与是否伴有肿瘤转移有显著差异(P <0 0 5 ) ,而与性别、癌组织分化程度无关。结论 整合素αVβ3可能在胆管癌细胞的恶性生物学行为中具有重要的作用,检测整合素αVβ3表达可以作为胆管癌预后判断的依据之一。
Objective To study the expression of integrin α_Vβ_3 in human bile duct carcinomas and its correlation with clinical pathology. Methods Integrin α_Vβ_3 was detected with the immunohistochemical staining in the samples of bile duct carcinomas and of adjacent bile duct tissues from 47 patients. Results Integrin α_Vβ_3 was expressed in the bile duct carcinoma cells and the endotheliocytes of the new vessels in all 47 samples. Its expression intensity was found to have no relation to the sex and the differentiation of the tumor cells, but there was a remarkable difference between the groups with and without metastases (P<0.05). Conclusion Integrin α_Vβ_3 may play an important role in the malignant biological behavior of the bile duct carcinoma. Examination of this protein may be one of the indicators of the prognosis of the patients with bile duct carcinoma.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2005年第12期1276-1278,共3页
Journal of Third Military Medical University
关键词
胆管癌
整合素
肿瘤转移
bile duct carcinoma
integrin
metastasis
