摘要
将10名烧伤面积30％～60％含Ⅲ度伤的患者分为休克期组(n=5)和休克期后组(n=5),并设正常对照组(n=6),进行药代动力学比较研究。并通过高效液相法动态分析了应用头孢噻甲羧肟后,血浆、尿液和烧伤水疱液中的浓度。结果显示:休克期组与正常对照组比较差异有非常显著意义,表观分布容积(0.45±0.06L/kg 对0.23±0.05L/kg)、非肾清除率(30.54±21.97ml·min^(-1)对11.08±4.91ml·min^(-1))等虽增加,但药物的消除相半衰期却延长(3.20±1.12h 对1.89±0.15h)。提示在大面积烧伤的早期,用药剂量不需增加。烧伤病人水疱液中可测出有效的抑菌浓度,为1.004～21.62mg/L。证明早期全身性用药,可穿透Ⅱ度烧伤组织。
Pharmacokinetic studies were carried out following systemic administra- tion of ceftazidime in ten burn patients(TBSA 30%～60% and with full-thickness burn) and six healthy volunteers.Dynamic ceftazidime concentrations in blood,urine and blis- ter fluid were analysed by HPLC.The results showed that the burned patients,especially during their shock phase,some pharmacokinetics parameters differed from that of nor- mal volunteers,in that the volume of distribution (0.45±0.06L/kg vs.0.23±0.05 L/kg) and non-renal clearance of drug (30.54±21.97ml·min^(-1)vs.11.08±4.91 ml·min^(-1))increased,but the elimination of half-life was prolonged.The result indicated that it was not necessary to increase the dosage of ceftazidime in extentive burns in the early period.Burn blister fluid concentrations were higher than MIC.Ranging from 1.004～21.62μg/ml,indicating that systemic ceftazidime could penetrate second-degree burn tissue in the early postburn stage.
