摘要
实验组动物Wistar大鼠71只,昆明种小鼠51只,用碘缺乏病地区的饮水和粮食喂养,水碘含量为0.12μg/L,粮食碘含量为195.25μg/L。对照组Wistar大鼠28只,昆明种小鼠22只,用非碘缺乏病地区的饮水和粮食喂养,水碘含量为13.6μg/L,粮食碘含量为207.5μg/kg。实验开始后,分别于第4、7、12个月杀死各组动物总数的1/3,进行血清和病理学检查。结果,实验组动物因长期摄碘量不足而发生下列变化:(1)血清甲状腺素总量(TT4)降低,三碘甲状腺原氨酸总量(TT3)与其比值升高;(2)脑垂体前叶分泌促甲状腺激素(TSH)的嗜碱性细胞增生肥大,垂体重量显著增加;(3)血清TSH浓度显著升高;(4)甲状腺滤泡上皮细胞在TSH慢性刺激下显著增生,先后出现弥漫性甲状腺肿、结节性甲状腺肿、非典型性增生,最终突变形成甲状腺癌;(5)122只动物中共检出甲状腺癌19只(大鼠8只,小鼠11只),其中乳头状癌14只,滤泡性癌5只,检出率15.6%。对照组未查见甲状腺癌。提示TSH可能有促癌作用。
Abstract Wistar rats and Km mice were fed with a normal diet or a diet
deficient in iodine(0.12μg/liodide in drinking water and 195.3μg/kg iodide in the
grain,collected from an iodine deficientarea).The animals were sacrificed at 4,7 and 12 months,
one-third of the animals for each,respecti vely,after initation of the experiment.It was found that,
under iodine deficiency,thethyroid gland increased in weight with marked epithelial hyperplasia
of the follicles,and nodular,diffuse goiter,epithelial atypia which eventually progressed to
carcinoma in 19(8 rats and 11 mice)ofthe 122 animals studied. Histologically,papillary
carcinoma was observed in 14 and follicularcarcinoma in 5.No malignent tumor developed in
amimals on normal iodine intake. Moreorer,there was marked hyperplasia of basophilic cells in
the anterior pituitary with an increase in serumthyroid stimulating hormone(TSH)leve The
results suggest that,the development of thyroidcarcinoma is the result of feedback
hypersecretion of TSH in response to hypofunction of the thyroidgland due to iodine deficiency.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1994年第5期341-344,共4页
Chinese Journal of Oncology